Effectiveness of Hyaluronic Acid, Platelet-Rich Plasma, and Polyacrylamide Hydrogel Injections for Knee Osteoarthritis: a Comparative Prospective Cohort Study

This current research is a prospective, observational study evaluating hyaluronic acid viscosupplementation (HA), platelet-rich plasma (PRP), and polyacrylamide hydrogel (Arthrosamid) injections for knee osteoarthritis. Patients of all ages and OA grades are followed with HA and PRP at 1, 3, 6, 12 and 24 months, and Arthrosamid up to 5 years. Primary outcomes include WOMAC pain, stiffness and function scales, with secondary outcomes assessing VAS pain scales, functional tests, additional procedures, and safety. Subgroup analyses examine factors predicting treatment response. The study aims to describe trajectories of pain, function, safety, and overall injection effectiveness across the three therapies.