This study evaluates hyaluronic acid, PRP, and Arthrosamid injections for knee osteoarthritis, tracking pain, stiffness, function, and safety over time. It also examines which patients respond best, aiming to provide insight into the long-term effectiveness of these common injection therapies.

This triple-blind randomized trial compares polyacrylamide hydrogel (Arthrosamid) to hyaluronic acid and placebo for knee osteoarthritis. PAH is a long-lasting, non-biodegradable injectable with a strong safety record. The study evaluates pain relief, function, and safety to guide clinicians in selecting the most effective treatment for knee OA.